The lungs of prematurely born infants are often not fully functional and require extra ventilatory support until they reach maturity. Research has led to new insights into the subsequent growth and development of prematurely born children and the development of new technology for measuring lung function in the premature infant
Research in this area has shown how tidal volume is related to lung size , and how expiratory flow and the work of breathing changes in the presence of obstructive airway disease [1-4]. This research has been extended to define breathing patterns in a restrictive lung disease, idiopathic pulmonary fibrosis. Another research project aims to use Ion Mobility Spectrometry to analyse volatile compounds in the expired breath to diagnose respiratory disease, such as COPD and lung cancer.
1. Powell T, Neill., P. Williams, EM. (2009). Estimating FEV1 from tidal breathing
2. Powell T., EM Williams (2009). Letter to the Editor: Inspiratory muscle training in adults with COPD.
3. Powell, T., Williams, EM. (2012). Effect of Resistive Load on the Inspiratory Work and Power of Breathing during Exertion.
4. Williams EM, T Powell, M Eriksen, P Neill and R Colasanti (2013). A pilot study quantifying the shape of tidal breathing waveforms using centroids in health and COPD.